Intrahepatic cholangiocarcinoma
(ICC), a tumor with biliary tract differentiation pathologic features, is the
second most common primary liver cancer worldwide after HCC, accounting for
15-20% of all primary liver cancers; the incidence of ICC is on the rise,especially in Western Countries.
The morphologic classification system for
primary liver cancer proposed by the Liver Cancer Study Group of Japan divides
ICC into three types based on macroscopic appearance: the mass-forming type,the periductal infiltrative type, and the intraductal growing type.Mass-forming ICC (IMCC) is the most common type and shows a radial growth
pattern, invading into the adjacent hepatic parenchyma.
Combined
hepatocellular-cholangiocarcinoma (cHCC-CC), is a rare (incidence among primary
liver cancer ranges from 0.4% to 14%) but an increasingly recognized primary
malignant neoplasm in the liver.