The unconvincing response of test
molecules acquired in non-human systems is recognised as the major cause of
clinical botches. The unoriginal in vitro methods of drug discovery do nottruly represent the human system. However, the recent developments in Organoid
culture are motivating and elevating the hopes for replacing test animals with
artificial human tissues.
Late stage attritions in drug
discovery are costly and consuming. Improbable response of test molecules
acquired in non-human systems is attributed to be the major cause of clinical
failures. While conventional in vitro methods of drug discovery do not trulyrepresent the human system, the animal models used for in vivo validation are
also genetically and phenotypically distant from humans. However, recent
developments in organoid culture are motivating and elevate hopes for replacing
test animals with artificial human tissue models.