Botulinum
neurotoxins (BoNTs) are one of the powerful toxins in nature however the
toxicity is immediately eradicated by the tough environment in the digestive
system because BoNTs are simply the proteins.
However, BoNTs can reach synaptic
junctions because of support of other protein by aggregating with one another,
merging with BoNTs and building a sizable progenitor toxin complicated (L-PTC).
To be able to clarify the way the complex formation permits the BoNTs tointrude into the body, we discovered that the three-dimensional framework of
the L-PTC involves an ovoid body with three feet and speculated important
functions in the torso and the lower limbs. In the feet part, it is effective
for promoting absorption especially from the tiny intestine.
Because
experimental results showed that the legs are have and flexible specific
binding sites of saccharides, the L-PTC may be helped by the flexibilities to
easily gain access to the binding sites to the saccharides on the intestinal
surface. However, such flexibilities have been only investigated byexperimental methods. Which means that we still have not objectively talked
about what movements are made from the condition of the L-PTC and the way the
structure is evolved steadily?